Keep discovering.

Indus Pharma experience and expertise will enable you to take a molecule from bench to bedside.

Safer, greener and more efficient processes
Flexibility with reactors – static and dynamic
Ability to handle complex chemistry
Scale-up on ton scale
Continuous manufacturing – reaction, work up, isolation
Temperature: -20⁰C to +150⁰C
Pressure: 100 bar
Reactions handled: nitration, bromination, lithiation, alkylation, cyclopropanation

Micellar chemistry
- Use of proprietary and commercially available surfectants
- Routine reactions with water as solvent
- Easy isolation of product by avoiding conventional work-up conditions
- Green and economically viable – biodegradable and recyclable surfectants
Pincer catalysis
- Screening with Anthem’s proprietary and commercially available Pincer complexes
- Atom economical reductions of carbonyl compounds using molecular hydrogen as the reductant
- Apt solution for hydrogenation, dehydrogenation, aromatization of dihydro- heterocycles
- Better alternative to hazardous pyrophoric metal hydrides
- Ease of isolation avoiding excessive solid waste generation

Design of novel chemical entities (NCEs) based on concepts of drug design and in collaboration with In silico Molecular Modelling Group
Design and synthesis of novel chemical entities to identify hit, lead and optimized lead, with prior IPR evaluation
Design of pharmaceutically acceptable salts, pro-drugs to improve solubility, bioavailability and efficacy
Proprietary Natural Products inspired library (over 100,000 compounds) for target classes – protein kinases, proteases, GPCR, ion-channel, NHRs, phosphodiesterases, Ubiquitin/Proteasome etc.
Biological profiling of the synthesized compounds based on in vivo in vitro, and pharmacokinetics data

QbD based design and development of API’s – ICH Q9/Q11 – FMEA/Risk assessment
Enhanced approach for development using statistical tools
Synthetic route design – Novel, non-infringing, faster, safer and more economical
Optimizing the process to have scalable and robust control strategy
Process optimization focusing on optimum reaction conditions and reagent quantities, minimum cycle time, maximum concentrations and telescoping of steps
CMC and DMF support
Synthesis of high potent APIs (HP APIs) – upto OEB 5
Toxin, linker – toxin conjugates and ADCs
Peptide synthesis – upto 40 amino acids
PEG, Gal-NAc, steroid conjugated and phospholipids

Facilities